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Index > Protein center > NPR3(Gene name) > Human
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  • NPR3 (Gene name),
  • Atrial natriuretic peptide receptor 3 (Protein name ),  ANPRC_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    NPR3(ANPRC;C5orf23;NPRC);
    Protein name:
    Atrial natriuretic peptide receptor 3;
    Alternative:
    Atrial natriuretic peptide receptor type C(ANP-C;ANPR-C;NPR-C);Atrial natriuretic peptide clearance receptor;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer; disulfide-linked. Dimers can also be formed through the C-terminal cysteine of isoform 2.
    Function:
    Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    541
    Sequence:
    50:
    MPSLLVLTFS | PCVLLGWALL | AGGTGGGGVG | GGGGGAGIGG | GRQEREALPP | 
    100:
    QKIEVLVLLP | QDDSYLFSLT | RVRPAIEYAL | RSVEGNGTGR | RLLPPGTRFQ | 
    150:
    VAYEDSDCGN | RALFSLVDRV | AAARGAKPDL | ILGPVCEYAA | APVARLASHW | 
    200:
    DLPMLSAGAL | AAGFQHKDSE | YSHLTRVAPA | YAKMGEMMLA | LFRHHHWSRA | 
    250:
    ALVYSDDKLE | RNCYFTLEGV | HEVFQEEGLH | TSIYSFDETK | DLDLEDIVRN | 
    300:
    IQASERVVIM | CASSDTIRSI | MLVAHRHGMT | SGDYAFFNIE | LFNSSSYGDG | 
    350:
    SWKRGDKHDF | EAKQAYSSLQ | TVTLLRTVKP | EFEKFSMEVK | SSVEKQGLNM | 
    400:
    EDYVNMFVEG | FHDAILLYVL | ALHEVLRAGY | SKKDGGKIIQ | QTWNRTFEGI | 
    450:
    AGQVSIDANG | DRYGDFSVIA | MTDVEAGTQE | VIGDYFGKEG | RFEMRPNVKY | 
    500:
    PWGPLKLRID | ENRIVEHTNS | SPCKSSGGLE | ESAVTGIVVG | ALLGAGLLMA | 
    541:
    FYFFRKKYRI | TIERRTQQEE | SNLGKHRELR | EDSIRSHFSV | A
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    SMR:
    String:
    KEGG:
    MIM:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Atrial natriuretic peptide receptor 3
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    E9980h
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    ELISA Kit for Human Atrial natriuretic peptide receptor 3
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    E9980b
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    Packing:
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    ELISA Kit for Human Atrial natriuretic peptide receptor 3
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    E9980r
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    ELISA Kit for Human Atrial natriuretic peptide receptor 3
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    E9980m
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    Packing:
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    CLIA Kit for Human Atrial natriuretic peptide receptor 3
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    U9980m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Atrial natriuretic peptide receptor 3
    Cat.:
    U9980h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Atrial natriuretic peptide receptor 3
    Cat.:
    U9980b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Atrial natriuretic peptide receptor 3
    Cat.:
    U9980r
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Atrial natriuretic peptide receptor 3
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    P9980Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Atrial natriuretic peptide receptor 3
    Cat.:
    P9980Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Atrial natriuretic peptide receptor 3
    Polyclonal Antibody for Human Atrial natriuretic peptide receptor 3
    Cat.:
    P9980Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Atrial natriuretic peptide receptor 3
    Monoclonal Antibody for Human Atrial natriuretic peptide receptor 3
    Monoclonal Antibody for Human Atrial natriuretic peptide receptor 3
    Monoclonal Antibody for Human Atrial natriuretic peptide receptor 3
    Protein for Human Atrial natriuretic peptide receptor 3
    Protein for Human Atrial natriuretic peptide receptor 3
    Protein for Human Atrial natriuretic peptide receptor 3
    Protein for Human Atrial natriuretic peptide receptor 3

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    Linearity
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    References
    1. 1.
      "cDNA sequence of the human atrial natriuretic peptide clearance receptor."
      Lowe D.G. , Camerato T.R. , Goeddel D.V.
      Nucleic Acids Res.18:3412-3412(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Kidney.
    2. 2.
      "Isolation and functional expression of the human atrial natriuretic peptide clearance receptor cDNA."
      Porter J.G. , Arfsten A. , Fuller F. , Miller J.A. , Gregory L.C. , Lewicki J.A.
      Biochem. Biophys. Res. Commun.171:796-803(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "Human lens epithelial mRNA for atrial natriuretic peptide clearance receptor."
      Rae J.L. , Shepard A.R.
      Submitted (1997-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Lens epithelium.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Pericardium.
    5. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    7. 8.
      "The disulfide linkages and glycosylation sites of the human natriuretic peptide receptor-C homodimer."
      Stults J.T. , O'Connell K.L. , Garcia C. , Wong S. , Engel A.M. , Garbers D.L. , Lowe D.G.
      Biochemistry33:11372-11381(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE (ISOFORMS 1 AND 2);DISULFIDE BONDS;GLYCOSYLATION AT ASN-86; ASN-293 AND ASN-394;STRUCTURE OF CARBOHYDRATES
    8. 9.
      "Extracellular domain-IgG fusion proteins for three human natriuretic peptide receptors. Hormone pharmacology and application to solid phase screening of synthetic peptide antisera."
      Bennett B.D. , Bennett G.L. , Vitangcol R.V. , Jewett J.R. , Burnier J. , Henzel W. , Lowe D.G.
      J. Biol. Chem.266:23060-23067(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: LIGAND-BINDING
    9. 10.
      "Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone."
      He X.-L. , Chow D.-C. , Martick M.M. , Garcia K.C.
      Science293:1657-1662(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 44-485 IN COMPLEX WITH NATRIURETIC PEPTIDE;GLYCOSYLATION AT ASN-293 AND ASN-394;DISULFIDE BONDS;SUBUNIT
    10. 11.
      "Structural determinants of natriuretic peptide receptor specificity and degeneracy."
      He X.-L. , Dukkipati A. , Garcia K.C.
      J. Mol. Biol.361:698-714(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 1-480 IN COMPLEX WITH NATRIURETIC PEPTIDE AND CHLORIDE IONS;GLYCOSYLATION AT ASN-86; ASN-293 AND ASN-394;DISULFIDE BONDS
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